Drug Standards
eMolecules Medchem Express / Oxibendazole / 50mg / 446272455 / HY-B0299 / / 20559-55-1 / MFCD00847838 / 249.270 / C12H15N3O3
Medchem Express / Oxibendazole / 50mg / 446272455 / HY-B0299 / / 20559-55-1 / MFCD00847838 / 249.270 / C12H15N3O3
Cayman Chemical Itraconazole 100mg
An antifungal agent and hedgehog pathway inhibitor; inhibits hedgehog signaling (IC50 = 0.8 μM); binds to 14-α sterol demethylase/CYP51 isoform B (Kd = 31 nM for A. fumigatus enzyme expressed in E. coli); inhibits ergosterol biosynthesis in C. neoformans (IC50 = 6 nM after 16 hours); inhibits C. neoformans growth by 50% at 3.2 nM; suppresses growth of medulloblastomas in a Ptch+/-p53-/- mouse allograft model at 100 mg/kg twice daily; reduces viral titers of several enteroviruses in infected cells from 1.25-100 µM
Cayman Chemical Suc-YVAD-AMCacetate 1mg
A fluorogenic substrate for caspase-1; upon enzymatic cleavage, AMC is released and its fluorescence can be used to quantify caspase-1 activity; ex/em = 340-360/440-460 nm, respectively
Medchemexpress LLC Tebipenem pivoxil | 161715-24-8 | 99.7% | 497.63 | 10 MG
Tebipenem pivoxil is an orally active antibiotic that works against various pathogenic bacteria. It functions by binding to penicillin-binding protein (PBP), thereby inhibiting bacterial cell wall synthesis. It exhibits excellent antibacterial activity against a range of pathogenic bacteria.
- Orally active antibiotic
- Inhibits cell wall synthesis by binding to penicillin-binding protein (PBP)
- Exhibits excellent antibacterial activity against pathogenic bacteria
- Inhibits Gram-positive and Gram-negative bacteria with MIC50s below 64 μg/mL
- Significantly increased survival in sepsis mouse models
Cayman Chemical Abnormal Cannabidiol
An analytical reference standard that is structurally similar to known phytocannabinoids; not found in Cannabis; has been used as an internal standard for the detection of cannabinoids in hemp extracts; intended for research and forensic applications
Cayman Chemical Gabapentin Inhibitors
An analgesic and anticonvulsant; inhibits current-induced signal transmission and reduces glutamatergic excitatory postsynaptic potentials in isolated rat striatal neurons (EC50s = 320.4 and 96.8 µM, respectively); inhibits glutamate-induced membrane depolarization in isolated rat striatal neurons at 100 or 300 µM; decreases mechanical and cold allodynia in rats at 60 mg/kg; reduces plasma levels of Tnf-α and Il-1β and increases sciatic nerve levels of GSH and decreases sciatic nerve levels of MDA in a rat model of vincristine-induced neuropathic pain; decreases the number of MES-induced seizures in rats (ED50 = 14.8 mg/kg)
Medchemexpress LLC (R)-Naproxen | 23979-41-1 | C14H14O3 | 100 MG
l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. It can inhibit Cdc42 and Rac1 with EC50 values of 96 μM and 212 μM, respectively, and exhibits anti-tumor activity. l-Naproxen is also a nonsteroidal anti-inflammatory agent (NSAID). In HeLa cells, l-Naproxen selectively inhibits Rac1 and Cdc42 activity in a dose-dependent manner. It also inhibits the migration of immortalized human ovarian cancer cells and demonstrates activity through a COX-independent mechanism.
- Inhibits Cdc42 and Rac1 with EC50 values of 96 μM and 212 μM
- Demonstrates anti-tumor activity
- Acts as a nonsteroidal anti-inflammatory agent (NSAID)
- Selectively inhibits Rac1 and Cdc42 activity in HeLa cells
- Inhibits migration of immortalized human ovarian cancer cells
- Shows activity via a COX-independent mechanism
Medchemexpress LLC Diclofenac acid | 15307-86-5 | C14H11Cl2NO2 | 10 G
Diclofenac is a potent and nonselective anti-inflammatory agent. It acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. It also induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
- Targets COX
- Induces apoptosis of neural stem cells (NSCs)
- Supports immunology and inflammation research
- Suitable for laboratory and R&D use
- Available as a crystalline powder
Selleck Chemical LLC Simvastatin 25mg 79902-63-9 MK-0733
Simvastatin (MK-0733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Flavopiridol | 146426-40-6 | >=95.0% | 401.84 | C21H20ClNO5 | 1 G
Flavopiridol (Alvocidib) is a small-molecule, ATP-competitive cyclin-dependent kinase (CDK) inhibitor used in research to study cell cycle regulation, transcriptional control, and apoptosis. It exhibits potent inhibition of multiple CDKs and is supplied for laboratory and biochemical assays.
- Broad-spectrum, ATP-competitive inhibition of cyclin-dependent kinases for cell cycle studies.
- Potent activity with reported IC50 values of 30 nM (CDK1), 170 nM (CDK2), and 100 nM (CDK4).
- Applicable to apoptosis and transcription regulation research involving CDK pathways.
- Provided as a characterized research chemical with documented CAS number and molecular weight.
- Suitable for in vitro biochemical assays and cellular studies when handled per safety guidance.
TARGETMOL CHEMICALS INC Nocodazole 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis. Purity 99.34%
Cayman Chemical Fenbendazole-d3 1mg
An internal standard for the quantification of fenbendazole by GC- or LC-MS
Apexbio Technology LLC Chlorhexidine digluconate 18472-51-0 50mg
Chlorhexidine digluconate (18472-51-0) is a small-molecule antimicrobial agent It exerts its biological activity primarily through perturbation of bacterial cell membrane integrity causing disruption of membrane function and subsequent bacterial cell death In typical microbiological assays chlorhexidine digluconate demonstrates inhibitory activity with reported IC50 values generally ranging from 1 to 10 g/mL against several bacterial species Based on these pharmacological properties chlorhexidine digluconate holds research potential in infection control antimicrobial sensitivity assays microbial pathogenesis and cellular membrane permeability studies