Drug Standards
Medchemexpress LLC Detomidine hydrochloride | 90038-01-0 | 99.83% | 1 ML
Detomidine hydrochloride is an imidazole derivative and a potent α2-adrenergic agonist. It produces dose-dependent analgesic effects. This product is for research use only and not sold to patients.
- Potent α2-adrenergic agonist
- Produces dose-dependent analgesic effects
- Exhibits cardiac and respiratory effects
- Has an antidiuretic action
- Available in solid and solution forms
- For research use only
Medchemexpress LLC Tizanidine-d4 | 1188331-19-2 | 99.9% | 1 MG
Tizanidine-d4 is a deuterium labeled version of Tizanidine, a skeletal muscle relaxant and central α2-adrenoceptor agonist. It works by inhibiting the release of excitatory amino acids from spinal cord interneurons, reducing muscle spasticity. Tizanidine-d4 also shows anti-injury activity, can inhibit GI transport, and may inhibit proliferation, migration, and invasion of lung cancer cells by inducing cell apoptosis through specific signaling pathways. It is used to treat spasticity from conditions like multiple sclerosis, stroke, and spinal cord injury.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Exhibits anti-injury activity
- Can inhibit gastrointestinal (GI) transport
- May inhibit proliferation, migration, and invasion of lung cancer cells
- Induces cell apoptosis by upregulating Nischarin and inhibiting AKT and Wnt3a/β-catenin signaling pathways
Medchemexpress LLC Fluticasone propionate | 80474-14-2 | 99.93% | 500 MG
Fluticasone propionate is a potent topical anti-inflammatory corticosteroid. It acts as a selective glucocorticoid receptor agonist, exhibiting an absolute affinity (KD) of 0.5 nM. The product shows minimal to no activity at other steroid receptors and also possesses anti-viral activity.
- Potent topical anti-inflammatory corticosteroid
- Selective glucocorticoid receptor agonist
- Absolute affinity (KD) of 0.5 nM
- Minimal to no activity at other steroid receptors
- Possesses anti-viral activity
Medchemexpress LLC Fluticasone propionate | 80474-14-2 | 99.9% | 5 MG
Fluticasone propionate is a potent topical anti-inflammatory corticosteroid and a selective glucocorticoid receptor agonist with an absolute affinity (KD) of 0.5 nM. It exhibits minimal or no activity at other steroid receptors and also possesses anti-viral activity.
- Potent topical anti-inflammatory corticosteroid.
- Selective glucocorticoid receptor agonist with a KD of 0.5 nM.
- Exhibits minimal or no activity at other steroid receptors.
- Possesses anti-viral activity.
- Has an EC50 of 0.7 nM for transactivation activity at glucocorticoid receptor in HepG2 cells.
- Shows an ED50 of 3 μg for anti-inflammatory activity in neutrophils.
- Achieves an IC50 of 0.1 nM for inhibition of TNFalpha release in PBMC.
- Demonstrates an EC50 of 1.09 nM for agonist activity at GR in SW1353 cells.
- Inhibits TNFα-induced E-selectin expression with an IC50 of 1 nM.
Medchemexpress LLC Methylprednisolone | 83-43-2 | 99.78% | 5 G
Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. It has been shown to improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. It is commonly used for anti-inflammatory purposes and in the study of various inflammatory conditions.
- Synthetic corticosteroid with anti-inflammatory and immunomodulating properties
- Can improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels
- Commonly used for anti-inflammatory purposes
- Can be used in the study of bronchial inflammation or acute bronchitis caused by arthritis and various respiratory diseases
- Can improve neurological recovery in acute spinal cord injury
- Triggers osteoblast death through multiple pathways, inducing femoral head necrosis
Medchemexpress LLC Glipizide (Standard) | 29094-61-9 | 99.7% | 100 MG
Glipizide (Standard) is an analytical standard intended for research and analytical applications. This potent, orally active sulfonylurea class anti-diabetic agent is used for type 2 diabetes mellitus research, acting by partially blocking ATP-sensitive potassium channels among β cells of pancreatic islets of Langerhans.
- Analytical standard for research and analytical applications
- Potent, orally active sulfonylurea class anti-diabetic agent
- Used for type 2 diabetes mellitus research
- Acts by partially blocking ATP-sensitive potassium (KATP) channels
- Reference standard supplied assay
- Commonly used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS
Medchemexpress LLC Nitisinone | 104206-65-7 | 99.93% | 1 ML
Nitisinone is an orally active, competitive, and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. It promotes tyrosine accumulation in a dose-dependent manner.
- Used in studies of hereditary tyrosinemia type 1 (HT-1)
- Used in studies of albinism
- Orally active
- Competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor
Medchemexpress LLC Fenticonazole Nitrate | 73151-29-8 | 98.86% | 50 MG
Fenticonazole Nitrate is an antifungal imidazole ring derivative that hinders ergosterol integration and destructs the cytoplasmatic outer membrane. It is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis.
- Antifungal imidazole ring derivative.
- Operates by hindering ergosterol integration.
- Destructs the cytoplasmatic outer membrane.
- Effective against Gram-positive bacteria.
- Effective against mycoses.
- Effective against vaginal candidiasis.
Medchemexpress LLC Diphenhydramine (Standard) | 58-73-1 | 98.7% | 50 MG
Diphenhydramine (Standard) is the analytical standard of Diphenhydramine, intended for research and analytical applications. It is a first-generation histamine H1-receptor antagonist with anti-cholinergic effects. Diphenhydramine hydrochloride can cross the ovine blood-brain barrier (BBB). This compound is an analytical standard used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications.
- First-generation histamine H1-receptor antagonist.
- Possesses anti-cholinergic effect.
- Diphenhydramine hydrochloride can cross the ovine blood-brain barrier (BBB).
- Commonly used in HPLC, GC, and MS for qualitative, quantitative, and methodological research experiments.
Medchemexpress LLC Hydrochlorothiazide | 58-93-5 | MFCD00051765 | 99.5% | 5 G
Hydrochlorothiazide (HCTZ) is an orally active thiazide diuretic that inhibits the TGF-β/Smad signaling pathway and has direct vascular relaxant effects. It improves cardiac function, reduces fibrosis, and exhibits an antihypertensive effect by reducing sodium reabsorption in the kidneys and lowering peripheral vascular resistance.
- Orally active diuretic agent
- Inhibits the TGF-β/Smad signaling pathway
- Direct vascular relaxant effects by opening KCA channels
- Improves cardiac function
- Reduces fibrosis
- Antihypertensive effect
- Reduces blood volume by decreasing sodium reabsorption
- Induces natriuresis and concomitant water loss
- Increases calcium reabsorption
Medchemexpress LLC Niclosamide (olamine) | 1420-04-8 | 98.7% | 5 G
Niclosamide olamine (BAY2353) is an orally active antihelminthic agent used in parasitic infection research. It is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide olamine has biological activities against cancer and inhibits DNA replication in Vero E6 cells.
- Functions as an orally active antihelminthic agent in parasitic infection research.
- Acts as a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells.
- Shows biological activity against cancer.
- Inhibits DNA replication in Vero E6 cells.
- Inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells.
- Inhibits STAT3-mediated luciferase reporter activity in HeLa cells.
- Inhibits virus replication in Vero E6 cells.
Medchemexpress LLC Ranitidine | 66357-35-5 | 99.9% | 250 MG
Ranitidine is a potent, selective, and orally active histamine H2-receptor antagonist that inhibits gastric secretion. It antagonizes histamine-induced increases in guinea-pig isolated rat atrium and histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. It also inhibits breast tumor development and spread in mice.
- Inhibits gastric secretion
- Antagonizes histamine-induced increases in guinea-pig isolated rat atrium
- Antagonizes histamine-induced relaxations of the rat isolated uterine horn
- Inhibits breast tumor development and spread in mice
- Reduces CD11b+Ly6Chi cells in spleen and bone marrow
- Inhibits lung metastasis
- Inhibits primary tumor growth
- Increases the latency of breast tumorigenesis and reduces tumor count
Medchemexpress LLC Betahistine dihydrochloride | 5579-84-0 | 99.8% | 5 G
Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. It is commonly used in the study of rheumatoid arthritis (RA).
- Orally active histamine H1 receptor agonist
- H3 receptor antagonist
- Used for the study of rheumatoid arthritis (RA)
- Inhibits [125I]iodoproxyfan binding to CHO cell membranes
- Regulates cAMP formation in CHO cells
- Attenuates severity of arthritis and reduces pro-inflammatory cytokines in paw tissues of CIA mice
- Ameliorates mouse CIA by decreasing joint destruction
Medchemexpress LLC Fexofenadine hydrochloride | 153439-40-8 | 99.9% | 5 MG
Fexofenadine hydrochloride is an orally active and nonsedative H1 receptor antagonist. It can be used in allergic rhinitis and chronic idiopathic urticarial research.
- Orally active
- Nonsedative H1 receptor antagonist
- Can be used in allergic rhinitis research
- Can be used in chronic idiopathic urticarial research
- Inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner
- Blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts
- Suppresses eosinophilia and systemic anaphylaxis in T. spiralis infected mice
Medchemexpress LLC Betahistine dihydrochloride | 5579-84-0 | 99.8% | 500 MG
Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and H3 receptor antagonist. It is used for the study of rheumatoid arthritis (RA).
- Orally active histamine H1 receptor agonist
- Histamine H3 receptor antagonist
- Inhibits [125I]iodoproxyfan binding to CHO cell membranes
- Regulates cAMP formation in CHO cells
- Increases tele-methylhistamine (t-MeHA) levels in vivo
- Attenuates the severity of arthritis in CIA mice
- Reduces pro-inflammatory cytokines in paw tissues